TH protein and mRNA in nigrostriatal dopaminergic neurons are down-regulated by continuous but not intermittent apomorphine

Authors
Iwata, S Nomoto, M Kaseda, S Tanoue, S Shimosaka, M Fukuda, T
Citation
S. Iwata et al., TH protein and mRNA in nigrostriatal dopaminergic neurons are down-regulated by continuous but not intermittent apomorphine, MOL BRAIN R, 82(1-2), 2000, pp. 133-136
Citations number
16
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
82
Issue
1-2
Year of publication
2000
Pages
133 - 136
Database
ISI
SICI code
0169-328X(20001020)82:1-2<133:TPAMIN>2.0.ZU;2-K
Abstract
Levels of tyrosine hydroxylase (TH) and TH mRNA were measured after adminis tration of dopamine agonists for a long period of time to elucidate the lon g-term feedback inhibition of dopamine synthesis in nigrostriatal dopaminer gic neurons. Continuous infusion, which desensitized presynaptic dopamine r eceptors, but not repeated administration, down-regulated TH and TH mRNA le vels. This suggests levels of TH protein and mRNA are only feedback inhibit ed by the continuous stimulation of postsynaptic dopamine receptors. (C) 20 00 Elsevier Science B.V. All rights reserved.