Peripheral neuropathy associated with acquired immunodeficiency syndrome (A
IDS)-related Burkitt's lymphoma usually occurs as a toxic effect of chemoth
erapeutic agents. Whereas primary peripheral nerve involvement is an unusua
l complication, we report on a human immodeficiency virus (HIV)-positive pa
tient with Burkitt's lymphoma and sciatic neuropathy due to compression by
a lymphomatous mass. Therapy with radiation and chemotherapy was followed b
y clinical and radiological improvement, but recurrent neurological deficit
s in a similar distribution occurred later from lymphomatous meningitis. (C
) 2000 John Wiley & Sons, Inc.