Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia?

Authors
Birklein, F Weber, M Neundorfer, B
Citation
F. Birklein et al., Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia?, NEUROLOGY, 55(8), 2000, pp. 1213-1215
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
8
Year of publication
2000
Pages
1213 - 1215
Database
ISI
SICI code
0028-3878(20001024)55:8<1213:ISLICR>2.0.ZU;2-H
Abstract
To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on pat ients with CRPS (n = 11) and healthy control subjects (n = 11). In addition , they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysi s, probably as a result of chronic tissue hypoxia.