Selective serotonin reuptake inhibitors have been used in the treatment of
depression in patients with PD. Conflicting data as to whether selective se
rotonin reuptake inhibitors worsen parkinsonian motor symptomatology have b
een reported. In this study, the additional 6 months therapy with paroxetin
e 20 mg/d in a group of depressed patients with PD did not modify parkinson
ian motor function (Unified Parkinson's Disease Rating Scale scores); howev
er, in one patient, fully reversible worsening of tremor was observed. Depr
ession, as evaluated by Beck Depression Inventory and Hamilton Depression R
ating Scale, improved from baseline to final visit (p < 0.05 by analysis of
variance).