[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding totranscription factor Sp1

Authors
Baraldi, PG Cacciari, B Guiotto, A Romagnoli, R Spalluto, G Leoni, A Bianchi, N Feriotto, G Rutigliano, C Mischiati, C Gambari, R
Citation
Pg. Baraldi et al., [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding totranscription factor Sp1, NUCLEOS NUC, 19(8), 2000, pp. 1219-1229
Citations number
34
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
8
Year of publication
2000
Pages
1219 - 1229
Database
ISI
SICI code
1525-7770(2000)19:8<1219:[(HIDB>2.0.ZU;2-5
Abstract
We designed and synthesized the hybrid 6, prepared combining the minor groo ve binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, re lated to the natural occurring anthramycin (2) and DC-81 (3). In this paper , the effects of the compound 6 on molecular interactions between DNA and t ranscription factor Spl were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.