Bcl-2 regulation targeting the Au-rich domain

Authors
Bevilacqua, A Ceriani, MC Schiavone, N Nicolin, A
Citation
A. Bevilacqua et al., Bcl-2 regulation targeting the Au-rich domain, NUCLEOS NUC, 19(8), 2000, pp. 1273-1279
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
8
Year of publication
2000
Pages
1273 - 1279
Database
ISI
SICI code
1525-7770(2000)19:8<1273:BRTTAD>2.0.ZU;2-Z
Abstract
In an effort to identify potential upregulators of bcl-2 activity in t(14;1 8) follicular B lymphoma cells, we detected a hybrid bcl-2/IgH RNA transcri bed in antisense orientation. This antisense transcript may contribute to u pregulation of bcl-2 expression in t(14;18) cells, overlapping AU-rich moti fs present in the 3'-untranslated region of bcl-2 mRNA. We have studied the enzymatic efficiency of a ribozyme directed towards the bcl-2 AU-rich regi on in a cell-free system determining its kinetic parameters.