PAcM-An: Poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides.

Authors
Bonora, GM De Franco, AM Rossin, R Veronese, FM Ferruti, P Plyasunova, O Vorobjev, PE Pyshnyi, DV Komarova, NI Zarytova, VF
Citation
Gm. Bonora et al., PAcM-An: Poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides., NUCLEOS NUC, 19(8), 2000, pp. 1281-1288
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
8
Year of publication
2000
Pages
1281 - 1288
Database
ISI
SICI code
1525-7770(2000)19:8<1281:PP(AO>2.0.ZU;2-L
Abstract
A new amphiphilic, high-molecular weight poly (N-acryloylmorphorine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liq uid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H act ivity. Its antisense activity against an HIV-1 target has been also evaluat ed.