Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria

Authors
Giacometti, A Cirioni, O Del Prete, MS Paggi, AM D'Errico, MM Scalise, G
Citation
A. Giacometti et al., Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria, PEPTIDES, 21(8), 2000, pp. 1155-1160
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
21
Issue
8
Year of publication
2000
Pages
1155 - 1160
Database
ISI
SICI code
0196-9781(200008)21:8<1155:CSBPPA>2.0.ZU;2-H
Abstract
The in vitro interaction between five polycationic peptides, buforin II, ce cropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates o f Gram-positive and Gram-negative aerobic bacteria, using the microbroth di lution method. The combination studies showed synergy between ranalexin and polymyxin E, doxycycline and clarithromycin. In addition, magainin II was shown to be synergic with betalactam antibiotics. (C) 2000 Elsevier Science Inc. All rights reserved.