There is a high coexistence of substance abuse in humans with eating disord
ers. One theory offered to account for this fact is that a common biochemic
al substrate may exist that mediates both processes. Brain neuropeptide Y (
NPY) is one neurochemical system that might contribute to these separate, y
et related, problems. To clarify the role of NPY in mediating reward proces
ses and the possible interaction between reward and feeding, the present st
udy examined the effects of injecting NPY bilaterally into the perifornical
hypothalamus (PFH) vs. the nucleus accumbens (NAC) on intake of preferred
vs. non-preferred food types, as well as on conditioned place preference (C
PP) learning. NPY (24, 78, 156 and 235 pmol/side) stimulated intake of both
regular powdered chow and sucrose when injected into the PFH, but not the
NAG. A CPP that was negatively col related with food intake occurred with t
he low (24 pmol/side) dose of NPY in the PFH, while a CPP that was not corr
elated with food intake was produced with the same dose in the NAG. The ext
ent of the CPPs produced by NPY injection in both brain sites mirrored that
produced by peripheral injection of amphetamine (2.5 mg/kg). These results
indicate that NPY elicits reward-related behavior, but not feeding, from t
he NAG, and both behaviors from the PFH. However, the feeding effect derive
d from the PFH appears to overshadow a rewarding effect derived from this s
ite. Considered together, these findings suggest that altered NPY functioni
ng in both brain regions may contribute to some of the pathophysiological p
rocesses observed in eating disordered patients who have additional procliv
ities for substance abuse. (C) 2000 Elsevier Science Inc. All rights reserv
ed.