Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides

Nine bis-acridine derivatives have been synthesized in search of structures with antiviral properties. Synthesis of target compounds was provided by a standard peptide-like coupling procedure using aliphatic diamines and prot ected amino acids following protective group removing and acridinylation by means of 9-methoxyacridine. Two out of nine compounds tested demonstrate h igh protective activity of Vero cells against HSV infection. Antiviral acti vity was observed only for compounds containing a pentamethylene fragment a s a linker. The alanyl-containing derivative was less active than those con taining valyl- and phenylalanyl. Most of synthesized compounds were less to xic than N,N'-bis-(acridinyl) hexamethylenediamine.