E. Castelli et al., Retroperitoneal lymphadenectomy and sexual disfunction in patients with testis and funicle tumours: our experience., PROG UROL, 10(4), 2000, pp. 578-582
Objectives : The aim of this study was to evaluate retrospectively the pres
ervation of fertility in a number of patients with testis or funicle tumour
treated with retroperitoneal lymph node dissection (RPLND).
Material and Methods : Between 1983 and 1998, 41 patients with testis or fu
nicle cancer (mean age 29 years, range 18-58) underwent RPLND at our instit
ution. Clinical staging included abdominal CT scan, chest X-rays and serum
tumour markers (alpha FP, beta HCG, LDH). RPLND was performed bilaterally i
n 14 patients and unilaterally in 13 patients (6 right and 7 left). The ner
ve sparing technique was used in 14 cases. Ejaculation was evaluated in 39
patients (2 patients died of metastases before the study). Mean follow up w
as 64 months (range 5-182). Semen was available for 21 patients before RPLN
D and for 19 patients after RPLND. The much less thant Student much greater
than test was used to compare the semen parameters before and after surger
y.
Results : Bilateral RPLND caused loss of ejaculation in 67% of the patients
(8/12). Unilateral right and left RPLND allowed to maintain ejaculation in
100% (6/6) and 57% (4/7) of cases respectively Nerve sparing procedure pre
served ejaculation in 100% of the patients (14/14). After RPLND, both mean
total sperm count and mean motility rate were not significantly changed (14
3 +/- 124 x 106 vs 128.2 +/- 72 x 106 p > 0.05; 40.7 +/- 17.6 vs 48 +/- 15.
5%, p > 0.05). The survival rate of the patients treated with RPLND was 95%
. None of the patients treated with unilateral (en bloc or nerve sparing) R
PLND had relapse.
Conclusion : The evolution of surgical technique has notably reduced the an
drological complications of the RPLND without affecting the oncological res
ults.