CVID (common variable immunodeficiency): heterogeneous clinical picture ofthe commonest symptomatic primary immunodeficiency disease

Common variable immunodeficiency is the most common symptomatic primary imm unodeficiency disease. The patients typically present with a long history o f respiratory tract infections, sometimes sarcoid-like lesions and in rare cases boils. Heterogeneity of initial clinical manifestations as well as in sufficient knowledge of the syndrome often delay the diagnosis. However, ea rly therapy is important to reduce infections and in particular the develop ment of bronchiectasis. Documenting 19 cases, we discuss initial clinical m anifestations, some clinical complications, diagnostic procedures and thera peutic management.