Dw. Stanleysamuelson et al., EICOSANOIDS MEDIATE NODULATION RESPONSES TO BACTERIAL-INFECTIONS IN LARVAE OF THE SILKMOTH, BOMBYX-MORI, Comparative biochemistry and physiology. Section A: Comparative physiology, 118(1), 1997, pp. 93-100
Citations number
35
Categorie Soggetti
Physiology,Biology
Journal title
Comparative biochemistry and physiology. Section A: Comparative physiology
1) Nodulation is the first, and qualitatively predominant, cellular de
fense reaction to bacterial infections in insects and other invertebra
tes; 2) treating silkworms, Bombyx mori, with the eicosanoid biosynthe
sis inhibitor, dexamethasone, strongly reduced nodulation responses to
bacterial infections; 3) the influence of dexamethasone was reversed
oy injecting the eicosanoid-precursor polyunsaturated ratty acid, arac
hidonic acid (20:4n-6), into dexamethasone-treated, infected larvae; 4
) the presence of an eicosanoid biosynthesis system in silkworms was d
ocumented. Demonstrated elements include a digestive phospholipase Az,
incorporation of exogenous 20:4n-6 into fat body phospholipids, the p
resence of 20:4n-6 in cellular phospholipids, a fat body intracellular
phospholipase A? that can hydrolyze 20:4n-6 from cellular phospolipid
s, and eicosanoid biosynthetic enzymes; and) these findings support th
e hypothesis that eicosanoids mediate cellular immune responses to bac
terial infections in silkworms. (C) 1997 Elsevier Science Inc.