Lymphatic mapping and sentinel node biopsy of operable breast cancer

The aim of this study was to evaluate the reliability and accuracy of senti nel node biopsy for invasive breast cancer and the predictability of axilla ry node status. Between January 1996 and June 1997 a total of 73 patients u nderwent patent blue dye lymphatic mapping and sentinel node biopsy followe d by standard (level I and II) axillary node dissection (one bilateral proc edure). The sentinel node was identified in 82.4% (61/74) of the cases and was predictive of axillary status in 96.7% (59/61). The false-negative rate of the procedure was 8.0% (2/25). The sentinel node was involved in 37.7% (23/61) and was the only one invaded in 30.4% (7/23). The sensitivity of th e procedure was 92% (CI95% 74-99%) and its specificity 100%. It is currentl y considered to be an attractive new procedure undergoing evaluation in pro spective controlled trials. This study confirmed the reliability and reprod ucibility of intraoperative lymphatic mapping and sentinel node biopsy. Thi s is the first step toward a new era of minimally invasive axillary surgery for breast cancer.