Zebrafish functional genomics

Artemis Pharmaceuticals have just announced a second saturation mutagenesis screen of the zebrafish, Danio vevio. In this interview with Stefan Schult e-Merker, who is Head of Fish Genetics at Artemis, we find out more about t he purpose of the second screen and contrast it with the first screen which was carried out in Christaine Nusslein-Volhard laboratory and which is now called 'Tubingen One'. Stefan Schulte-Merker has been working with zebrafish for over ten years an d was involved in a number of genetic screens. He was also part of a team t hat produced a first-generation map of the 'Goodfellow panel' of radiation hybrids, which was intended to help in the cloning of the mutated genes. He is currently Head of Fish Genetics at Artemis Pharmaceuticals, in Tubingen , who are in the process of a second-round genetic screen, called 'Tuibinge n 2000'. Copyright (C) 2000 John Wiley & Sons, Ltd.