As the HIV epidemic continues to affect at-risk and vulnerable populations,
providers strive to improve prevention programs, in part by seeking new in
terventions with greater effects. Although interventions with scientific ev
idence of effectiveness are vital to this effort, many challenges limit acc
ess to research products. We examine key challenges and offer a framework f
or moving research to practice, one in which research steps are Linked to p
ractice steps and all these activities take place in a complex and dynamic
environment. The Replicating Effective Programs (REP) project of the Center
s for Disease Control and Prevention and other technology transfer activiti
es illustrate the operation of this framework for HIV prevention. Further a
ctions to improve technology transfer are called for. These include reducin
g time from study design to practice; learning from field-based implementat
ions; providing guidance about fidelity to, and tailoring of, science-based
interventions; improving linkages among consumers, providers, and research
ers; and seeking additional resources.