Assessment of blood flow velocity and diameter of the middle cerebral artery during the acetazolamide provocation test by use of transcranial Dopplersonography and MR imaging
Sj. Schreiber et al., Assessment of blood flow velocity and diameter of the middle cerebral artery during the acetazolamide provocation test by use of transcranial Dopplersonography and MR imaging, AM J NEUROR, 21(7), 2000, pp. 1207-1211
Citations number
26
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Neurosciences & Behavoir
BACKGROUND AND PURPOSE: Our purpose was to show changes in the diameter of
the M1 segment of the middle cerebral artery (MCA) by using high-resolution
MR imaging in patients with chronic internal carotid artery occlusion afte
r TV administered acetazolamide challenge. Changes in blood flow velocity o
f the basal cerebral arteries are thought to correlate with changes of cere
bral blood how, Changes in the diameter of the basal cerebral arteries, how
ever, might influence the validity of transcranial Doppler measurements.
METHODS: Eight patients with internal carotid artery occlusion who were und
ergoing acetazolamide testing for assessment of cerebrovascular vasomotor r
eactivity were included in the study. Blood how velocities of both MCAs wer
e measured with transcranial Doppler sonography before and 25 minutes after
the administration of acetazolamide. Before and 15 minutes after the admin
istration of medication, MR imaging was performed contralateral to the occl
usion side. A T2-weighted turbo-gradient spin-echo sequence was chosen to s
how a cross section of the M1 segment in high resolution (pixels, 0.27 x 0.
29 mm), Based on interpolated data, the smallest and greatest MCA diameters
were determined.
RESULTS: We did not find changes in the diameter of the MCA after acetazola
mide provocation testing with high-resolution MR imaging in patients with o
cclusive extracranial carotid artery disease.
CONCLUSION: The results of our study support the hypothesis that changes in
MCA flow velocity measured by transcranial Doppler sonography reflect rela
tive changes in cerebral blood how after acetazolamide provocation testing.