25 years kidney transplantation analysis

Between 1975 and 2000, 1008 renal transplantations were performed in 935 re cipients at Henri Mondor hospital. The mean objective of this study is to a nalyse patient and graft survivals at long term. For kidney transplantation s performed respectively before and after 1985, ten years patient survival was 74.3% +/- 0.03 and 85.7% +/- 0.01, p = 0.03 and ten years graft surviva l was 39.5% +/- 0.04 and 71.9% +/- 0.02 after 1985, p = 0.001. Since 1985, an enhancement in graft actuarial survival still improved (one year surviva l 86.1% +/- 0.01 Versus 90.8% +/- 0.02, three years survival 78.5% +/- 0.02 versus 85.5% +/- 0.02, five years survival 71.7% +/- 0.02 versus 78.8% +/- 0.04, for the years 1985-1994 Versus 1995-2000, p +/- 0.05). Immunosuppres sive drugs may contribute to results enhancement in kidney transplantation while other non immunologic factors are becoming more predominant. (C) 2000 Editions scientifiques et medicales Elsevier SAS.