Animal models and preclinical development of anti-osteoporosis compounds.

Authors
Ammann, P Rizzoli, R Bonjour, JP
Citation
P. Ammann et al., Animal models and preclinical development of anti-osteoporosis compounds., ANN MED IN, 151(5), 2000, pp. 380-384
Citations number
12
Categorie Soggetti
General & Internal Medicine
Journal title
ANNALES DE MEDECINE INTERNE
ISSN journal
0003410X → ACNP
Volume
151
Issue
5
Year of publication
2000
Pages
380 - 384
Database
ISI
SICI code
0003-410X(200009)151:5<380:AMAPDO>2.0.ZU;2-I
Abstract
BACKGROUND Rat model Mouse model Other animal models INVESTIGATION METHODS In vivo evaluation of bone density and bone architect ure Biomechanics Bone histology Biochemical markers of hone remodeling INVESTIGATION PROTOCOLS Pharmacokinetics Treatments Evaluation of hone tole rance (effect of drugs on bone metabolism) Importance of preclinical evalua tion CONCLUSION.