Northwest African distribution of the CD4/Alu microsatellite haplotypes

Citation
C. Flores et al., Northwest African distribution of the CD4/Alu microsatellite haplotypes, ANN HUM GEN, 64, 2000, pp. 321-327
Citations number
23
Categorie Soggetti
Molecular Biology & Genetics
Journal title
ANNALS OF HUMAN GENETICS
ISSN journal
00034800 → ACNP
Volume
64
Year of publication
2000
Part
4
Pages
321 - 327
Database
ISI
SICI code
0003-4800(200007)64:<321:NADOTC>2.0.ZU;2-C
Abstract
We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwe st Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.7 5), and weaker association Between the microsatellite allele 90 and Alu(-) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic dines for the five major haplotype s suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(-) in t his area is congruent with an ancient and autochthonous human presence in N orthwest Africa.