Pp. Schachter et al., The impact of laparoscopy and laparoscopic ultrasonography on the management of pancreatic cancer, ARCH SURG, 135(11), 2000, pp. 1303-1307
Hypothesis: Laparoscopy and laparoscopic ultrasonographic (LAPUS) examinati
ons combined with a biopsy of the pancreatic lesion contribute significantl
y in the determination of resectability of pancreatic cancer.
Design: A prospective evaluation of the impact of laparoscopy and LAPUS on
surgical decision making in patients with pancreatic cancer.
Setting: A general community hospital; the department of surgery serves as
referral for pancreatic surgery.
Patients: During a 36-month period, 94 patients with pancreatic lesions wer
e prospectively examined. Twenty-seven patients were found to have advanced
disease. The remaining 67 patients were examined by laparoscopy and LAPUS
to determine the resectability of the pancreatic tumor.
Results: Laparoscopy and LAPUS contributed new, additional data in 40 patie
nts (60%). Advanced disease was found in 30 patients, precluding curative r
esection. The study indicated potentially resectable tumors in 37 patients
(55%), including 3 defined by conventional imaging studies as probably unre
sectable, and these patients were operated on with the intention of curativ
e resection. Thirty-three patients underwent resection, and 4 (6%) were fou
nd to have nonresectable disease and form the false-positive group of the s
tudy. A summary of the results shows that the study resulted in a change of
the decision regarding surgical intervention in 24 patients (36%) and avoi
ded unnecessary laparotomies in 21 (31%). The study had a sensitivity of 10
0%, a specificity of 88%, and a false-positive rate of 6%. The positive pre
dictive value of the study is 89%, and the negative predictive value is 100
%.
Conclusions: Although rather invasive procedures that require general anest
hesia and hospitalization, laparoscopy and LAPUS significantly contribute t
o the staging of patients with potentially resectable pancreatic cancer, av
oiding unnecessary explorative laparotomies. These procedures should be per
formed in all patients with potentially resectable pancreatic cancer before
explorative laparotomy.