Anaerobic formation of succinate and facilitation of its oxidation: Possible mechanisms of cell adaptation to oxygen deficiency

Authors
Maevsky, EI Grishina, EV Rosenfeld, AS Zyakun, AM Vereshchagina, VM Kondrashova, MN
Citation
Ei. Maevsky et al., Anaerobic formation of succinate and facilitation of its oxidation: Possible mechanisms of cell adaptation to oxygen deficiency, BIOFIZIKA, 45(3), 2000, pp. 509-513
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOFIZIKA
ISSN journal
00063029 → ACNP
Volume
45
Issue
3
Year of publication
2000
Pages
509 - 513
Database
ISI
SICI code
0006-3029(200005/06)45:3<509:AFOSAF>2.0.ZU;2-8
Abstract
An important role of anaerobic formation of succinate in anoxic and hypoxic states and the activation of succinate oxidation under hypoxia were shown. It was concluded that, for maintaining the energetics of animal cells unde r conditions of oxygen deficiency, it is advisable to use substrates capabl e of participating in the anaerobic formation of succinate, whereas under h ypoxia it is reasonable to use succinate itself.