Antiallergic effect of apple polyphenols on the allergic model mouse

We studied here the antiallergic effect of apple condensed tannins (ACT) ad ministered orally to a type I allergy model mouse transplanted with an IGEL a2 hybridoma secreting anti-2,4,6-trinitropbeoyl (TNP) immunoglobulin E (I gE). The oral administration of ACT significantly inhibited the ear swellin g responses at Ih after antigen-stimulation with picryl chloride. The respo nse was dose dependent within 0.1 to 10 mg/mouse. The inhibition of the ear swelling response leached the maximal level (90% inhibition) when ACT was administered 2 h before the antigen challenge. These findings suggest that ACT has an antiallergic effect on type I allergic symptoms.