Effect of epinephrine on GLUT2 protein content in mouse liver

The intraperitoneal administration of epinephrine (EP) to mire caused a sig nificant increase in the blood glucose level and a significant decrease in the liver glycogen content 1 h after its administration at 0.6 mg/kg (blood glucose; p<0.01, Liver glycogen; p<0.01), The liver type glucose transport er (GLUT2) mRNA expression and protein content from mouse liver significant ly increased in the intraperitoneally EP-treated mice when compared to that in normal mice (mRNA; p<0.01, protein; p<0.01). These results suggest that the haperglycemic effect of EP is due, at least in part, to the increase o f GLUT2 protein synthesis.