Catch-up growth in 166 small-for-gestational age premature infants weighing less than 1,000 g at birth

Catch-up growth was studied in 166 children born with an extremely low birt h weight (<1,000 g) and small-for-gestational age (SGA, <10th percentile bi rth weight for gestational age). Of these children 159 were followed up for between 4 and 18 years (median 9 years). Group A, SGA <10th percentile of Lubchenco curves only; group B, <10th percentile of Mamelle's curves but >5 th percentile, and group C, <5th percentile of Mammelle's curves. Catch-up growth was considered to be achieved when height,:weight, and head circumfe rence (HC) reached -2 SD of French reference data and remained above this l imit afterwards. Catch-up growth in height was achieved in 126/156 children or 81% (group A 88%; group B 84%; group C 74%), before 3 years of age in 1 00/127 (78%). Seven children below -2 SD received growth hormone (1 child w ho caught up was excluded from the results). Catch-up growth in weight was achieved in 126/159 children or 79% (group A 86%; group B 82%; group C 73%) , before 3 yea rs of age in 87/126 (69%). Catch-up growth in HC was achieve d in 126/156 or 81% (group A 78%; group B 92%; group C 77%), before 3 years of age in 102/127 (80%). Overall catch-up growth was achieved for all thre e parameters in 65% of children, two of three parameters in 19%, and one of three parameters in 8%. Eleven children never caught up on any parameter. While weight is a lesser concern and HC is not liable to intervention, a gr eater number of short children might benefit from growth hormone therapy. C opyright (C) 2000 S. Karger AG, Basel.