Stability of bioreductive drug delivery systems containing melphalan is influenced by conformational constraint and electronic properties of substituents

Authors
Weerapreeyakul, N Hollenbeck, RG Chikhale, PJ
Citation
N. Weerapreeyakul et al., Stability of bioreductive drug delivery systems containing melphalan is influenced by conformational constraint and electronic properties of substituents, BIOORG MED, 10(21), 2000, pp. 2391-2395
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
21
Year of publication
2000
Pages
2391 - 2395
Database
ISI
SICI code
0960-894X(20001106)10:21<2391:SOBDDS>2.0.ZU;2-6
Abstract
The stability of bioreductive drug delivery systems (TDDS) was monitored at various pH values and in the presence of glutathione (GSH). Results sugges t that steric hindrance due to conformational constraint in TDDS led to an increase in stability of TDDS toward nucleophilic degradation under aqueous conditions. The electronic properties of substituents influenced TDDS stab ility at different pH values and in the presence of GSH. (C) 2000 Published by Elsevier Science Ltd.