Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer

Authors
Kitajima, H Nakamura, M Tamakawa, H Goto, N
Citation
H. Kitajima et al., Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer, BIOORG MED, 10(21), 2000, pp. 2453-2456
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
21
Year of publication
2000
Pages
2453 - 2456
Database
ISI
SICI code
0960-894X(20001106)10:21<2453:HONISA>2.0.ZU;2-1
Abstract
Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidine dione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in po tency of insulin-releasing activity and to pioglitazone in insulin-sensitiz ing activity. (C) 2000 Elsevier Science Ltd. All rights reserved.