L-selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases

Authors
Zhou, ZS Smith, AE Matthews, RG
Citation
Zs. Zhou et al., L-selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases, BIOORG MED, 10(21), 2000, pp. 2471-2475
Citations number
32
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
21
Year of publication
2000
Pages
2471 - 2475
Database
ISI
SICI code
0960-894X(20001106)10:21<2471:LOSFLA>2.0.ZU;2-4
Abstract
A single-step convenient synthesis of L-selenohomocysteine (SeHcy) from L-s elenomethionine (SeMet) using sodium in liquid ammonia is described. Methio nine synthases convert SeHcy to SeMet at rates comparable to their rates of conversion of L-homocysteine (Hcy) to L-methionine (Met). This study sugge sts that SeHcy generated from SeMet metabolism can be efficiently recycled to SeMet in mammals. (C) 2000 Elsevier Science Ltd. All rights reserved.