Modulation of the Cs2CO3-promoted catalytic amination by a crown ether

Authors
Torisawa, Y Nishi, T Minamikawa, J
Citation
Y. Torisawa et al., Modulation of the Cs2CO3-promoted catalytic amination by a crown ether, BIOORG MED, 10(21), 2000, pp. 2489-2491
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
21
Year of publication
2000
Pages
2489 - 2491
Database
ISI
SICI code
0960-894X(20001106)10:21<2489:MOTCCA>2.0.ZU;2-9
Abstract
The catalytic addition of 18-Crown-6 in some Cs2CO3-promoted amination of t riflates and bromides was beneficial to improve sluggish reaction with supp ression of the unwanted side products. The protocol was useful for the prep aration of chlorinated aryl piperazines from phenol derivatives. (C) 2000 E lsevier Science Ltd. All rights reserved.