Intranasal midazolam for prolonged convulsive seizures

In order to determine the efficiency of intranasal midazolam in prolonged c onvulsive episodes, we conducted a prospective study in children with vario us types of seizures. Nine patients (six buys, three girls; age range 6 mon ths to 9 years) with prolonged convulsions lasting more than 10 min were tr eated with intranasal midazolam, 0.3 mg/kg. The success rate was 100% with only one case requiring a second dose. Estimated duration of seizures was 1 2-30 min (mean 18.6) while mean time elapsed until cessation of seizures wa s 139.6 s (range 60-480). No significant adverse effects were noted except fur one patient who had seizures secondary to serious CNS infection and res piratory depression after intranasal midazolam. (C) 2000 Elsevier Science B .V. All rights reserved.