Complications and tolerance of heated intraperitoneal chemotherapy and cytoreductive surgery for peritoneal carcinomatosis: results of a phase I-II study of peritoneal carcinomatosis from different sources
S. Antoun et al., Complications and tolerance of heated intraperitoneal chemotherapy and cytoreductive surgery for peritoneal carcinomatosis: results of a phase I-II study of peritoneal carcinomatosis from different sources, B CANCER, 87(9), 2000, pp. 665-670
Peritoneal carcinomatosis represents the terminal stage of adenocarcinomas
of the gastrointestinal tract. A new treatment combining cytoreductive surg
ery and intraperitoneal chemotherapy-hyperthermia has been used with encour
aging results. The purpose of this study was to report the complications as
sociated with this treatment Fourty procedures were carry out in 37 patient
s. Death occurred in 3 patients. Major medical complications were 13 pulmon
ary infections, II acute renal failure (with only 3 who needed dialysis) an
d 10 patients with neutropenia grade 3 and 4 toxicity. Intra-abdominal comp
lications occurred in 16 patients (there were II anastomotic leak and/or bo
wel perforation, and 12 intra-abdominal infections). Some complications lik
e secretory, diarrhea or tubulopathia which were related to these treatment
need further investigations. Six procedures were without any complications
, 6 presented minor ones and 22 major complications. Adverse effects were r
elatively important with this new treatment strategy. This was maybe due to
a learning process; there is no death and only one anastomotic leak in our
last study including 30 patients with cytoreductive surgery and intraperit
oneal chemotherapy-hyperthermia.