A novel beta-glucuronidase inhibiting triterpenoid from Paeonia emodi

Authors
Nawaz, HR Malik, A Khan, PM Shujaat, S",Atta-ur-Rahman
Citation
Hr. Nawaz et al., A novel beta-glucuronidase inhibiting triterpenoid from Paeonia emodi, CHEM PHARM, 48(11), 2000, pp. 1771-1773
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
11
Year of publication
2000
Pages
1771 - 1773
Database
ISI
SICI code
0009-2363(200011)48:11<1771:ANBITF>2.0.ZU;2-M
Abstract
A navel beta -glucuronidase inhibiting triterpene (1) has been isolated fro m the chloroform fraction of Paeonia emodi. Its structure has been establis hed as 1 beta ,3 beta ,5 alpha ,23,24-pentahydroxy-30-norolean-12,20(29)-di en-28-oic acid on the basis of spectroscopic analysis, including high resol ution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1,5-dihydroxy-3- methyl-anthraquinone are also reported for the first time from Paeonia emod i.