Inhibitory effects of 2 '-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation

Authors
Lim, SS Jung, SH Ji, J Shin, KH Keum, SR
Citation
Ss. Lim et al., Inhibitory effects of 2 '-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation, CHEM PHARM, 48(11), 2000, pp. 1786-1789
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
11
Year of publication
2000
Pages
1786 - 1789
Database
ISI
SICI code
0009-2363(200011)48:11<1786:IEO2'O>2.0.ZU;2-X
Abstract
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for t he prevention or the treatment of chronic diabetic complications, 5'-chloro -1,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhib ited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 mug/m l, respectively) but showed relatively weak inhibitory activities on RLAR.