A new caffeoyl quinic acid from Aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase

Authors
Kwon, HC Jung, CM Shin, CG Lee, JK Choi, SU Kim, SY Lee, KR
Citation
Hc. Kwon et al., A new caffeoyl quinic acid from Aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase, CHEM PHARM, 48(11), 2000, pp. 1796-1798
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
11
Year of publication
2000
Pages
1796 - 1798
Database
ISI
SICI code
0009-2363(200011)48:11<1796:ANCQAF>2.0.ZU;2-5
Abstract
The phytochemical study of the aerial parts of Aster scaber THUNB. (Asterac eae) yielded a new caffeoyl quinic acid, (-) 3,5-dicaffeoyl-muco-quinic aci d (2) and three known compounds, (-) 3,5-dicaffeoyl quinic acid (1), (-) 4, 5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structure s were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3,5-Dic affeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC 50 value of 7.0 +/- 1.3 mug/ml.