Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica

Authors
Shin, DY Kim, HS Min, KH Hyun, SS Kim, SA Huh, H Choi, EC Choi, YH Kim, J Choi, SH Kim, WB Suh, YG
Citation
Dy. Shin et al., Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica, CHEM PHARM, 48(11), 2000, pp. 1805-1806
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
11
Year of publication
2000
Pages
1805 - 1806
Database
ISI
SICI code
0009-2363(200011)48:11<1805:IOAPAS>2.0.ZU;2-O
Abstract
A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davi diana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as ma nsonone F (1), This compound has been found to be highly active specificall y against MRSA and showed an MIC range of 0.39-3.13 mug/ml which is compara ble to that of vancomycin.