SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME -3'-YL)-3-4-DIHYDRO-6-SUBSTITUTED-1,3-BENZOXAZINES AND 1-(3',5'-DISUBSTITUTED -YL)-2,3-DIHYDRO-2-OXO-4,6(1H,5H)-PYRIMIDINEDIONES

Substituted-2'-phenylindol-3'-imino)-5-substituted methylphenols (IIIa -i) on reduction with sodium borohydride followed by treatment with fo rmaldehyde yielded -3'-yl)-3,4-dihydro-6-substituted-1,3-benzoxazines (Va-i). 1-(3',5'-Disubstituted ndol-2'-yl)-3-(5-substituted-2'-phenyli ndol-3'-yl) ureas (VIIa-o) were synthesised by the reaction of la-c wi th 3,5-disubstituted indole-2-carboxy azides (Vla-e), while (VIIa-o) o n treatment with diethyl malonate in the presence of sodium ethoxide a fforded 1-(3'-5'-disubstituted '-phenylindol-3'-yl)-2,3-dihydro-2-oxo- 4,6-(1H,5H) pyrimidinediones (VIIIa-o). All these compounds have been tested for their antibacterial activity against E. coli, S. aureus and P. vulgaris and antifungal activity against A. niger and C. albicans. Compounds (VIIIa-o) were screened for their analgesic activity, some of the compounds showed good antibacterial, antifungal and analgesic a ctivity.