Pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage: Case report and literature review of central nervous system pseudallescheriasis

Pseudallescheria boydii and its asexual form, Scedosporium apiospermum, are ubiquitous, saprophytic fungi that commonly cause cutaneous infection. How ever, in certain circumstances, P. boydii can also cause invasive disease, which can involve the central nervous system (CNS). When the CNS becomes in volved, treatment is difficult, therapeutic options are limited, and the pr ognosis is poor. We report a case of Pseudallescheria brain abscess success fully treated with surgical drainage and systemic voriconazole, the first s uch case to be described in the literature. We also review previously repor ted cases of CNS pseudallescheriasis and evaluate therapeutic options.