Infections are common in long-term care facilities. The most frequent endem
ic infections are urinary infection, respiratory infection, and skin and so
ft tissue infections. Outbreaks also occur frequently, and some facilities
have a high prevalence of colonization of residents with antimicrobial-resi
stant organisms. Our understanding of infections and the development of inf
ection-control programs for long-term care facilities have progressed great
ly over the past 15 years. Whereas the occurrence of infections has been de
scribed and specific guidelines for infection-control programs in long-term
care facilities have been developed, there is still limited evaluation of
the effectiveness of programs or specific interventions to support prioriti
zation of infection-control resources. In addition, the spectrum of patient
s and care delivered in longterm care facilities continues to evolve. Incre
asingly, chronic care patients, including those requiring chronic respirato
r therapy, dialysis, or percutaneous feeding tubes, are cared for in these
facilities. Our understanding of prevention of infection in these patients
remains limited. Important questions include what interventions may prevent
endemic infections, what are the most effective means to identify outbreak
s early, and what interventions may minimize the prevalence of antimicrobia
l-resistant organisms. Programs to optimize antimicrobial use need to be de
veloped. Thus, although progress in understanding and practice has been mad
e, important questions remain.