Treatment of latent tuberculosis infection in patients aged >= 35 years

Authors
Gilroy, SA Rogers, MAM Blair, DC
Citation
Sa. Gilroy et al., Treatment of latent tuberculosis infection in patients aged >= 35 years, CLIN INF D, 31(3), 2000, pp. 826-829
Citations number
14
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
31
Issue
3
Year of publication
2000
Pages
826 - 829
Database
ISI
SICI code
1058-4838(200009)31:3<826:TOLTII>2.0.ZU;2-P
Abstract
Treating patients aged greater than or equal to 35 years for tuberculosis i nfection has been controversial because of the hepatotoxic effects of isoni azid. A 2-year retrospective cohort study of outpatient medical records det ermined the completion rate in this age group and identified risk factors a ssociated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving c oncomitant medications and men who used alcohol.