A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus

Authors
Watanabe, S Yamaguchi, Y Hattori, M Chikamoto, H Matsumoto, N Suzuki, T Oonishi, M Horita, S Tokumoto, T Tanabe, K Shiraga, H Toma, H Ito, K
Citation
S. Watanabe et al., A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus, CLIN TRANSP, 14, 2000, pp. 30-32
Citations number
7
Categorie Soggetti
Surgery
Journal title
CLINICAL TRANSPLANTATION
ISSN journal
09020063 → ACNP
Volume
14
Year of publication
2000
Supplement
3
Pages
30 - 32
Database
ISI
SICI code
0902-0063(2000)14:<30:APVITK>2.0.ZU;2-S
Abstract
Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of r ejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem . Moreover, its bioava ilability and pharmakokinetics are highly variable. We experienced a case o f acute nephrotoxicity, in which the blood level rose about 10 times above the expected level. We found a peculiar vacuolization in the transplant bio psy specimen. This change showed a marked vacuolization of the tubular cell s, suggestive of acute nephrotoxicity by TAC.