Lower limb ischaemia is one of the determinants in the development of diabe
tic foot ulcers and the most important factor preventing their healing. The
re are a number of misleading factors masking the presence of atherosclerot
ic disease and tissue damage; these are reduced inflammatory response to in
fection, autosympathectomy and mediasclerosis, which all diminish the clini
cal suspicion of ischaemia. Therefore, adequate assessment of the lower lim
b circulation should be routinely performed in complicated diabetic foot. T
his evaluation can often be made with simple methods. In addition to clinic
al examination ankle/brachial pressure index, systolic toe pressure, plethy
smographic pulse volume recordings and simple hand-held Doppler auscultatio
n are most often sufficient to make a decision as to whether angiography is
needed or not. Duplex examination can give more profound information on th
e severity and extent of arterial occlusive disease, but the method is stro
ngly user-dependent. Early vascular consultation is mandatory in diabetic f
oot work-up and should be undertaken within 2 weeks if a new skin lesion sh
ows no tendency to heal. Long bypass grafting procedures and microvascular
free flap techniques have been shown to achieve excellent results in reliev
ing critical leg ischaemia, even in the presence of large foot lesions, and
should be used to prevent major amputation. The timing of various procedur
es is a controversial issue. Feet with small ulcers or restricted dry gangr
ena can be revascularised first, with minor amputations and local surgery o
f the ulcer being done thereafter. In the septic neuroischaemic foot, major
amputation may be unavailable but if the infection is not immediately life
-threatening the infected part of the foot should be drained and debrided p
roperly and left wide open, sometimes with a guillotine amputation in order
not to risk the bypass graft, which can be done a couple of days later. Co
pyright (C) 2000 John Wiley & Sons, Ltd.