H. Zhang et al., Toxicological evaluation of New Zealand deer velvet powder. Part I: acute and subchronic oral toxicity studies in rats, FOOD CHEM T, 38(11), 2000, pp. 985-990
Potential toxic effects of acute and subchronic dosage regimens of deer vel
vet powder have been assessed in rats following OECD guidelines. In the acu
te study, rats of both sexes were exposed to a single dose of 2 g/kg body w
eight. There was no mortality or other signs of toxicity during 14 days' ob
servation. Furthermore, no significant alteration either in relative organ
weights or their histology was discernible at terminal autopsy. In the 90-d
ay subchronic study, deer velvet was administered in 1 g/kg daily doses by
gavage to rats. A control group of rats received water only. There was no e
ffect on body weight, food consumption, clinical signs, haematology and mos
t parameters of blood chemistry including carbohydrate metabolism, liver an
d kidney function. No significant differences were seen between the mean or
gan weights of the adrenal, kidney and brain in rats treated with deer velv
et and control rats. However, there was a significant difference (P < 0.05)
in the group mean relative Liver weight (3.52 +/- 0.30 vs 3.81 +/- 0.26 g/
100 g body weight) of deer velvet-treated and control male rats. The gross
necropsy and pathological examination of rats treated with deer velvet did
not reveal any abnormalities in tissue morphology, Based on these results,
it may be concluded that rats had no deer velvet treatment-related toxicolo
gical and histopathological abnormalities at the doses administered, despit
e the observed minor changes in liver weight. (C) 2000 Elsevier Science Ltd
. All rights reserved.