Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma

Interest has focused on a recently identified gene, BCL10, thought to play an important role in the genesis of extranodal, marginal zone (MALT) lympho mas. This gene belongs to a family containing caspase recruitment domains ( CARD), that are involved in the apoptotic pathway. Translocations of the BC L10 gene to the immunoglobulin heavy chain locus at 14q32 have been describ ed. We report herein a case of MALT lymphoma showing t(1; 2)(p22; p12). The translocation was shown to involve the BCL10 gene and the immunoglobulin k appa light chain locus by fluorescence in situ hybridization. (C) 2000 Wile y-Liss, Inc.