Synthesis, NMR (H-1, C-13 and P-31), mass spectral studies and biological activity of 2-aryloxy/alkyl-6-methyl-1,3,2-dioxaphosphorino[5,4-b]pyridine-2-oxides

Synthesis of 2-aryloxy/alkyl/phenyl-6-methyl-4H-1,3,2-dioxaphosphorino[5,4- b]-pyridine-2-oxides has been accomplished by condensation of equimolar qua ntities of various substituted phenylphosphorodichloridates and alkylphosph onic dichlorides with 3-hydroxy-6-methyl-2-pyridine-methanol (lutidine diol ) in the presence of triethylamine in dry benzene-pyridine. Their structure s have been established by elemental analysis, IR, NMR (H-1, C-13 and P-31) and mass spectral data. A few compounds have been screened for their expec ted antibacterial and antifungal activities. All the compounds exhibit mole cular ions with high abundance and (M-OAr)(+) ions are the base peaks in th eir mass spectra. Long range C-P coupling constant values are evaluated.