Synthesis and antibacterial activities of some fluorine containing arylfurylpropenones, pyrazolines and N- acetylpyrazoline

Several fluorine containing arylfurylpropenones 3 have been synthesized sta rting from arylfurfurals 1 and 2,4-dichloro-5-fluoroacetophenone 2. These a rylfurylpropenones are then used for the synthesis of fluorine containing a rylfurylpyrazolines 4. The newly synthesized pyrazolines are then converted into their N-acetyl derivatives 5. The structures of these compounds have been confirmed on the basis of elemental analysis, IR, NMR and mass spectra l studies. The mechanism for the formation of pyrazolines has been investig ated. The above compounds are also subjected to antibacterial screening. Th eir minimal inhibitory concentration (MIC) values indicate that some of the se compounds exhibit excellent antibacterial activities.