Ga. El-hiti et al., Synthesis and antimicrobial activities of novel sugar (2-phenylquinazolin-4-yl)hydrazones and their osazones, I J CHEM B, 39(5), 2000, pp. 368-376
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
Condensation of equimolar amounts of 4-hydrazino-2-phenylquinazoline 1 and
a number of monosaccharides 2 (D-glucose, D-galactose, D-xylose, D-arabinos
e and D-ribose) affords the corresponding hydrazones 3-7 in good yields. Ho
wever, when three molar equivalents of 1 is allowed to react with 2 in the
presence of glacial acetic acid, the corresponding osazones 13-16 are obtai
ned in fair yields. Acetylation of the hydrazones 3-7 and osazones 13-16 gi
ve the corresponding acetyl derivatives 8-12 and 17-20. The products obtain
ed have been characterized by spectral data and elemental analyses. Some of
the compounds show antifungal and antibacterial activities.