A 61-year-old man with a mixed carcinoid-adenocarcinoma of the liver is des
cribed. Microscopic examination of the lesion showed a differentiated adeno
carcinoma with distinct carcinoid components that stained positively for ar
gyrophil. The tumor cells contained serotonin granules on immunohistochemic
al studies. Detailed examination disclosed no primary tumor in the gastroin
testinal tract or in any other organ. Resection was considered impractical
because there were multiple tumors. The patient received chemotherapy six t
imes (cisplatin 60 mg/m(2), epirubicin 40 mg/ml per month). The multiple tu
mors gradually shrank, At the time of this writing, the patient is still al
ive. To our knowledge, this is the first reported case of mixed carcinoid-a
denocarcinoma of the liver.