Mixed carcinoid-adenocarcinoma of the liver

A 61-year-old man with a mixed carcinoid-adenocarcinoma of the liver is des cribed. Microscopic examination of the lesion showed a differentiated adeno carcinoma with distinct carcinoid components that stained positively for ar gyrophil. The tumor cells contained serotonin granules on immunohistochemic al studies. Detailed examination disclosed no primary tumor in the gastroin testinal tract or in any other organ. Resection was considered impractical because there were multiple tumors. The patient received chemotherapy six t imes (cisplatin 60 mg/m(2), epirubicin 40 mg/ml per month). The multiple tu mors gradually shrank, At the time of this writing, the patient is still al ive. To our knowledge, this is the first reported case of mixed carcinoid-a denocarcinoma of the liver.