Adapalene: an update on newer comparative studies between the various retinoids

Background Extensive modification of the retinoic acid molecular skeleton h as resulted in the development of adapalene, a more stable, less irritating compound with receptor selectivity. Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis. Pharmacologic and preclinical studies have demonstrated excellent follicular penetration, co medolytic activity, and anti-inflammatory activity. Methods Recent comparative trials were reviewed. Results Adapalene is a useful new agent because of its tolerability and sta bility. It is a good therapeutic choice for combination with other topical anti-acne medications, such as antimicrobials or benzoyl peroxide. Patient compliance with either combination or single-agent adapalene regimens is li kely to be enhanced because of the greater comfort and reduced skin irritat ion associated with the new compound. Other investigators have confirmed th at adapalene gel produces consistent and significantly reduced irritation. Conclusions Recent comparative trials on retinoids have provided new data t o aid in the selection of the appropriate combination of topical agents for individual patients.