Objective: To compare CO2 and normal saline as distention media in office d
iagnostic hysteroscopy. Methods: The outcome of more than 6000 office hyste
roscopies was analyzed. We used carbon dioxide or saline as distension medi
um. Minor hysteroscopic techniques were performed when indicated. Results:
The major indication was abnormal uterine bleeding (45%). Satisfactory hyst
eroscopy was achieved in 92.4% with CO2 and in 98.3% with saline (P < 0.05)
. Local anesthesia was used in 54 patients (1.5%) with CO2 and in three pat
ients (0.1%) with saline (P < 0.001). Four hundred and two women (16.3%) un
derwent hysteroscopic procedures under saline hysteroscopy. Endometrial pol
yps were removed in 281 patients, 75 IUDs were removed, 14 fibroids were ex
tracted, uterine septa were excised in 11 cases and mild and moderate adhes
ions were transected in 21 patients. Conclusion: Saline office diagnostic h
ysteroscopy offers at least all the advantages of the CO2 hysteroscopy, and
gives the possibility to easily 'find and treat in situ' many of the lesio
ns observed. (C) 2000 International Federation of Gynecology and Obstetrics
. All rights reserved.