P300 as a clinical assay: rationale, evaluation, and findings

Use of the P300 event-related brain potential (ERP) as a clinical assay is reviewed and assessed by comparing its distribution qualities with normativ e biomedical testing data from published studies. The coefficient of variat ion statistic was calculated for P300 data and a variety of clinical testin g data. P300 amplitude and latency variability was found to be highly compa rable and sometimes superior to routinely employed biomedical assays. These results are discussed in terms of how to control inter-group ERP variabili ty and the application of normative P300 data in clinical settings. (C) 200 0 Elsevier Science B.V. All rights reserved.